Int. J. Dev. Biol. 42: 325 - 333 (1998)
Special Issue: Developmental Genetics of Drosophila
Interactions between Wingless and Notch during the assignment of cell fates in Drosophila
Published: 1 April 1998
Abstract
A large number of observations suggest that, during Drosophila development there are close functional interactions between the activity of Notch receptor and that of a signaling molecule encoded by wingless gene. In this essay, I summarize these interactions and discuss the possibility that Wingless acts as a ligand for Notch as part of a switch that is iteratively involved in the assignation of cell fates during development.