Int. J. Dev. Biol. 42: 325 - 333 (1998)
© UPV/EHU Press

Interactions between Wingless and Notch during the assignment of cell fates in Drosophila.

A Martinez Arias

Department of Zoology, University of Cambridge, United Kingdom. ama11@cus.cam.ac.uk

ABSTRACT A large number of observations suggest that, during Drosophila development there are close functional interactions between the activity of Notch receptor and that of a signaling molecule encoded by wingless gene. In this essay, I summarize these interactions and discuss the possibility that Wingless acts as a ligand for Notch as part of a switch that is iteratively involved in the assignation of cell fates during development.