Expression of E-cadherin in embryogenetic ingression and cancer invasion.

M Mareel; M Bracke; F Van Roy; L Vakaet

doi:10.1387/ijdb.8507565

Linking Development, Stem Cells and Cancer Research

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Expression of E-cadherin in embryogenetic ingression and cancer invasion.

M Mareel, M Bracke, F Van Roy and L Vakaet

Department of Radiotherapy and Nuclear Medicine, University Hospital, Ghent, Belgium.

ABSTRACT Homophilic interactions of E-cadherin serve the organization of embryonic and adult epithelia and counteract cancer invasion. The role of E-cadherin as an invasion-suppressor molecule has been demonstrated cancer. Regulation of embryonic ingression and cancer invasion via E-cadherin occurs at transcriptional, translational and post-translation levels.