The enamelin (tuftelin) gene.

D Deutsch; A Palmon; L Dafni; J Catalano-Sherman; M F Young; L W Fisher

doi:10.1387/ijdb.7626400

Linking Development, Stem Cells and Cancer Research

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The enamelin (tuftelin) gene.

D Deutsch, A Palmon, L Dafni, J Catalano-Sherman, M F Young and L W Fisher

Department of Oral Biology, Hebrew University, Hadassah Faculty of Dental Medicine, Jerusalem, Israel.

ABSTRACT This paper reviews the primary structure, characteristics and possible function of tuftelin/enamelin protein. It describes the distribution of tuftelin in the ameloblast cell and in the extracellular enamel matrix, employing high resolution protein-A gold immunocytochemistry. The chromosomal localization of the human tuftelin gene and its possible involvement in autosomally linked Amelogenesis Imperfecta, the most common hereditary disease of enamel, is also discussed.