Int. J. Dev. Biol. 66: 333 - 347 (2022)
doi: 10.1387/ijdb.220072fj
© UPV/EHU Press

Intraflagellar transport 20 cilia-dependent and cilia-independent signaling pathways in cell development and tissue homeostasis

Fu-Chang Jin1, Ming-Hui Zhou1,2, Jing-Jing Chen1, Yi Lin1, Qi-Wei Zhang3, Qiu-Xian Xu4, Chang-Chun Zhang5, Zhen-Gang Zhang1,*

1Division of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2Division of Gastroenterology, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China, 3Jianghan University School of Medicine, Wuhan, China, 4Dongying People's Hospital, Shandong, China, 5Wuhan Sixth Hospital Affiliated to Jianghan University, Wuhan, China

ABSTRACT Intraflagellar transport (IFT) is an essential condition for ciliogenesis. The primary cilia protrude like antennae and act as chemical or mechanical sensory organelles that coordinate specific receptor localization and signal transduction. IFT20 is the smallest molecule in IFT complex B, which is located in both the cilia and the Golgi complex. Recent studies have shown that IFT20 is a key molecule in multiple signaling pathways. Importantly, in the function of IFT20, signal transduction is not restricted to cilia, but is also involved in non-ciliary functions. Here we summarize current knowledge regarding IFT20-mediated signaling pathways and their relationship with cell development and tissue homeostasis, and analyse the cilia-dependent and cilia-independent mechanisms of IFT20 coordinated signaling pathways and potential crosstalk between the mechanisms. This review provides a comprehensive perspective on IFT20 coordinates signaling mechanisms in cell development and tissue homeostasis.


primary cilia, Intraflagellar transport (IFT)20, cilia-dependent signaling pathways, cilia-independent signaling pathway

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