Int. J. Dev. Biol. 64: 465 - 469 (2020)
doi: 10.1387/ijdb.200242jc
© UPV/EHU Press

Reciprocal interactions between mesenchymal stem cells and macrophages

Małgorzata Kloc*,1,2,3, Ahmed Uosef1,2, Monika Leśniak4, Jacek Z. Kubiak4,5 and Rafik M. Ghobrial1,2

1Houston Methodist Research Institute, Houston, TX, USA 2Department of Surgery, Houston Methodist Hospital, Houston, TX, USA, 3University of Texas, M.D. Anderson Cancer Center, Department of Genetics, Houston, Texas, USA, 4Department of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology (WIHE), Warsaw, Poland and 5UnivRennes, UMR 6290, CNRS, Institute of Genetics and Development of Rennes (IGDR), Cell Cycle Group, Faculty of Medicine, Rennes, France

ABSTRACT Mesenchymal stem cells (MSCs) are used as therapeutic agents for the treatment of a wide spectrum of diseases, as well as for the regeneration and healing of burns and wounds. MSCs have an immunomodulatory effect and influence the phenotype and functions of immune cells, including macrophages, which in turn prime and license the MSCs. We discuss the new findings on the feedback loop between MSCs and macrophages and its consequences on the outcome of MSC therapies.

Keywords:

mesenchymal stem cell, MSC, macrophage, MSC therapy, immunomodulation

*Corresponding author e-mail: mkloc@houstonmethodist.org