Int. J. Dev. Biol. In Press
doi: 10.1387/ijdb.200231ja
© UPV/EHU Press

Establishing embryonic territories in the context of Wnt signaling

Ian Velloso1, Lorena A. Maia1,2, Nathalia G. Amado2, Alice H. Reis1, Xi He2, and Jose G. Abreu1,*

1Institute of Biomedical Sciences, Center of Health Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil and 2F. M. Kirby Neurobiology Center, Boston Children's Hospital, Department of Neurology, Harvard Medical School, Boston, MA, USA

ABSTRACT This review highlights the work that my research group has been developing, together with international collaborators, during the last decade. Since we were able to establish Xenopus laevis experimental model in Brazil we have been focused on understanding early embryonic patterns regarding neural induction and axes establishment. In this context, Wnt pathway appears as a major player and has been much explored by us and other research groups. Here we chose to review three published works that we consider landmarks within the history of our research on the developmental biology field and the neural induction and patterning modern findings. We intend to show how our series of discoveries, when painted together, tells a story that covers crucial developmental windows of early differentiation paths of anterior neural tissue. Being those: 1. Establishing Head organizer in contrast to trunk organizer at early gastrula; 2. deciding between neural ectoderm and epidermis ectoderm at the blastula/gastrula stages, and 3. the gathering of prechordal unique properties at late gastrula/early neurula.

Keywords:

reprogramming, pluripotency, expression vector, mouse strain

*Corresponding author e-mail: garciajr@icb.ufrj.br