Int. J. Dev. Biol. In Press
doi: 10.1387/ijdb.200227dq
© UPV/EHU Press

A Roadmap for Intestinal Regeneration

David Quispe-Parra, Griselle Valentín and José E. García-Arrarás*

Biology Department, University of Puerto Rico, Puerto Rico

ABSTRACT Regeneration of lost or injured organs is an intriguing process where numerous cellular events take place to form the new structure. Studies of this process during reconstitution of the intestine have been performed in echinoderms, particularly in holothurians. Many cellular events triggered during regeneration have been described using the sea cucumber Holothuria glaberrima as a research model. More recent experiments have targeted the molecular mechanism behind the process, a task that has been eased by the new sequencing technologies now available. In this review we present the studies involving cellular processes and the genes that have been identified to be associated with the early events of gut regeneration. We also present the ongoing efforts to perform functional studies necessary to establish the role(s) of the identified genes. A synopsis of the studies is given with the course of the regenerative process established so far.

Keywords:

gut regeneration, sea cucumber, echinoderms, holothurians

*Corresponding author e-mail: jegarcia@hpcf.upr.edu