Int. J. Dev. Biol. 62: 571 - 582 (2018)
doi: 10.1387/ijdb.170341fw
© UPV/EHU Press

Homeostasis, regeneration and tumour formation in the mammalian epidermis

Daria Belokhvostova, Ieva Berzanskyte, Ana-Maria Cujba, Geraldine Jowett, Lucy Marshall, Johanna Prueller and Fiona M. Watt*

King’s College London Centre for Stem Cells and Regenerative Medicine, Guy’s Hospital, London, UK

ABSTRACT The epidermis is the outer covering of the skin and provides a protective interface between the body and the environment. It is well established that the epidermis is maintained by stem cells that self-renew and generate differentiated cells. In this review, we discuss how recent technological advances, including single cell transcriptomics and in vivo imaging, have provided new insights into the nature and plasticity of the stem cell compartment and the differing roles of stem cells in homeostasis, wound repair and cancer.

Keywords:

skin, stem cell, plasticity, niche

*Corresponding author e-mail: Fiona.watt@kcl.ac.uk