Int. J. Dev. Biol. 60: 53 - 56 (2016)

https://doi.org/10.1387/ijdb.150307rs

Vol 60, Issue 1-2-3

Nucleolar protein 4-like has a complex expression pattern in zebrafish embryos

Developmental Expression Pattern | Published: 5 February 2016

Supriya Borah^1,2, Praveen Barrodia^1,2 and Rajeeb K. Swain*^,1

¹Institute of Life Sciences, Nalco Square, Chandrasekhar Pur, Bhubaneswar, Odisha, India and ²Manipal University, Manipal, Karnataka, India

Abstract

The nucleolar protein 4-like (NOL4L) gene is present on chromosome 20 (20q11.21) in humans. Parts of this gene have been shown to fuse with RUNX1 and PAX5 in acute myeloid leukemia and acute lymphoblastic leukemia, respectively. The normal function of NOL4L in humans and other organisms is not well understood. The expression patterns and functions of NOL4L homologs during vertebrate development have not been reported. We sought to address these questions by studying the expression pattern of zebrafish nol4l during embryogenesis. Our data show that Znol4l mRNA is expressed in multiple organs in zebrafish embryos. The sites of expression include parts of the brain, spinal cord, pronephros, hematopoietic cells and gut.

Keywords

diencephalon, telencephalon, trigeminal ganglia, spinal cord neuron, pronephros