Int. J. Dev. Biol. 59: 471 - 478 (2015)
doi: 10.1387/ijdb.150192ao
© UPV/EHU Press

Expression of Sox genes in tooth development

Katsushige Kawasaki1,2, Maiko Kawasaki2, Momoko Watanabe1, Erik Idrus1,3, Takahiro Nagai1, Shelly Oommen2, Takeyasu Maeda1, Nobuko Hagiwara4, Jianwen Que5, Paul T. Sharpe*,2 and Atsushi Ohazama*,1,2

1Division of Oral Anatomy, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, 2Department of Craniofacial Development and Stem Cell Biology, Dental Institute, King's College London, Guy's Hospital, London, UK, 3Division of Preventive Dentistry, Department of Oral Health Science, Niigata University, Graduate School of Medical and Dental Sciences, 4Division of Cardiovascular Medicine, UC Davis School of Medicine, Davis, CA, USA and 5Department of Medicine and Columbia Center for Human Development, Columbia University, New York, NY, USA

ABSTRACT Members of the Sox gene family play roles in many biological processes including organogenesis. We carried out comparative in situ hybridization analysis of seventeen sox genes (Sox1-14, 17, 18, 21) during murine odontogenesis from the epithelial thickening to the cytodifferentiation stages. Localized expression of five Sox genes (Sox6, 9, 13, 14 and 21) was observed in tooth bud epithelium. Sox13 showed restricted expression in the primary enamel knots. At the early bell stage, three Sox genes (Sox8, 11, 17 and 21) were expressed in pre-ameloblasts, whereas two others (Sox5 and 18) showed expression in odontoblasts. Sox genes thus showed a dynamic spatio-temporal expression during tooth development.

Keywords:

Sox, tooth development, in situ hybridization

*Corresponding author e-mail: atsushiohazama@dent.niigata-u.ac.jp ; paul.sharpe@kcl.ac.uk