Int. J. Dev. Biol. 58: 147 - 154 (2014)
doi: 10.1387/ijdb.130345wh
© UPV/EHU Press

Molecular determinants of uterine receptivity

Zhaowei Tu1,2, Hao Ran1,3, Shuang Zhang1, Guoliang Xia3, Bingyan Wang*,1 and Haibin Wang*,1

1State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 2Graduate School of the Chinese Academy of Sciences and 3State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, PR China

ABSTRACT Uterine receptivity is defined as a limited period when the uterine environment is conducive to blastocyst acceptance and implantation. Any disturbance of this early pregnancy event will compromise pregnancy success. In this review, we first briefly summarize uterine morphological coordination for the attainment of receptivity, then focus on elucidating the molecular complexity in establishing uterine receptivity and hence embryo implantation. A better understanding of the molecular basis governing uterine receptivity will help to improve the outcome of natural pregnancy and pregnancy conceived via assisted reproductive techniques.


uterine receptivity, molecular determinants

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