Male germ cells and cancer: a connection among pluripotency, differentiation and stem cell biology

Massimo De Felici; Susanna Dolci

doi:10.1387/ijdb.130167md

Linking Development, Stem Cells and Cancer Research

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Male germ cells and cancer: a connection among pluripotency, differentiation and stem cell biology

Massimo De Felici and Susanna Dolci

Rome, January 2013

ABSTRACT The development of male germ cells begins with the formation of the primordial germ cells (PGCs) and ends with that of sperm. During this process, spanning from the embryo to the adult age, there are points in which abnormalities in the corresponding processes can produce defective germ cells prone to tumour transformation.