Int. J. Dev. Biol. 57: 153 - 157 (2013)
doi: 10.1387/ijdb.130141jo
© UPV/EHU Press

Patient with two secondary somatic-type malignancies in a late recurrence of a testicular non-seminoma: illustration of potential and flaw of the cancer stem cell therapy concept

J.Wolter Oosterhuis*,1,#, Suzanne H.P. Peeters2,#, Vincent T.H.B.M. Smit3, Hans Stoop1, Leendert H.J. Looijenga1, Henk W. Elzevier2, Suzanne Osanto4

1Department of Pathology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands, 2Department of Urology, 3Department of Pathology and 4Department of Clinical Oncology, Leiden University Medical Center, The Netherlands

ABSTRACT Here, we report the case of a patient with a non-seminoma of the left testicle, with an intestinal-type adenocarcinoma and a low grade leiomyosarcoma in a late recurrence 19 years after initial diagnosis. The history of the patient, alive with disease 21 years after initial treatment, illustrates the potential and flaw of the cancer stem cell therapy concept. In addition, it is proposed that residual mature teratoma can be regarded as normalization of cancer due to embryonic patterning, and the development of a secondary somatic-type malignancy as failure of normalization.


case report, residual mature teratora, secondary non-germ cell malignancy, cisplatin, chemotherapy

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