Int. J. Dev. Biol. 43: 567 - 570 (1999)
© UPV/EHU Press

The role of RXR-alpha in retinoic acid-induced cleft palate as assessed with the RXR-alpha knockout mouse.

P Nugent, H M Sucov, M M Pisano and R M Greene

Department of Molecular, Cellular and Craniofacial Biology, University of Louisville School of Dentistry and University of Louisville Birth Defects Center, KY 40292, USA.

ABSTRACT Treatment of pregnant mice with retinoic acid (RA) in mid-gestation produces cleft palate and limb defects in the fetuses. RXR-alpha has been previously shown to mediate the teratogenic effects of RA in the limb. In this study, we show that RXR-alpha is also involved in retinoid-induced palatal clefting. Treatment of RXR-alpha knockout mice with a teratogenic dose of RA on gestation day 11 or 12 induces cleft palate at a lower frequency than that seen in wild-type animals.