A brief history of angiogenesis assays

Anca-Maria Cimpean; Domenico Ribatti; Marius Raica

doi:10.1387/ijdb.103215ac

Linking Development, Stem Cells and Cancer Research

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Int. J. Dev. Biol. 55: 377 - 382 (2011)
doi: 10.1387/ijdb.103215ac
© UPV/EHU Press

A brief history of angiogenesis assays

Anca-Maria Cimpean*^,1, Domenico Ribatti² and Marius Raica¹

¹Department of Histology, "Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania and ²Department of Human Anatomy and Histology, University of Bari Medical School, Italy

ABSTRACT The major problem with angiogenesis research is the choice of an appropriate assay. Currently, many in vitro and in vivo techniques are available for research into the functions of endothelial cells during angiogenesis. In this historical review article, we describe and evaluate the methodology and specific features of some of the most frequently used of these assays.

Keywords:

angiogenesis assay, endothelial cell, in vtro model, in vivo model

*Corresponding author e-mail: ancacimpean1972@yahoo.com