Large scale genetics in a small vertebrate, the zebrafish.

P Haffter; C Nusslein-Volhard

doi:10.1387/ijdb.8735932

Linking Development, Stem Cells and Cancer Research

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Large scale genetics in a small vertebrate, the zebrafish.

P Haffter and C Nüsslein-Volhard

Max-Planck-Institut für Entwicklungsbiologie, Tübingen, Germany.

ABSTRACT The systematic isolation and characterization of mutants in Drosophila has enormously facilitated the analysis of molecular mechanisms underlying developmental pathways in the embryo. A similar approach is presently being used to study embryonic development of the zebrafish, which is becoming a mainstream model organism for vertebrate development. With its genetic versatility and sophisticated embryology, zebrafish offers the possibility to rapidly increase our knowledge of vertebrate development and add to what we have learned from other vertebrate model organisms.