Int. J. Dev. Biol. 54: 919 - 924 (2010)
doi: 10.1387/ijdb.092916vm
© UPV/EHU Press

Identification and gastrointestinal expression of Xenopus laevis FoxF2

Valérie A. McLin*,1,2, Rina Shah3, Neekita P. Desai1 and Milan Jamrich3,4

1Department of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition, Baylor College of Medicine, 2Département de l’Enfant et de l’Adolescent, Unité de Gastroentérologie Pédiatrique, Hôpitaux Universitaires de Genève, Switzerland, 3Department of Cellular and Molecular Biology and 4Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA

ABSTRACT FoxF genes are essential for visceral mesoderm development from Drosophila to human. However, part of the difficulty of studying the visceral mesoderm is its relative inaccessibility during early development. Owing to its external development Xenopus laevis presents considerable advantages for the study of visceral mesoderm formation, yet FoxF2 has not been identified in this system. Here, we describe the cloning and expression pattern of XFoxF2 during embryonic development, metamorphosis and adulthood, and compare and contrast it to the expression of FoxF1 in Xenopus laevis and FoxF2 in mouse.

Keywords:

Xenopus, FoxF2, visceral mesoderm, intestine, metamorphosis

*Corresponding author e-mail: valerie.mclin@hcuge.ch