Vol. 62 Nos. 11/12 (2018) pp.653-876

Homeobox genes

Cover legend

The pioneering work of Ed Lewis, summarized in his founding paper published in Nature in 1978, forty years ago, revealed that the “homeotic” genes of the bithorax complex confer distinct identities to the different segments of the Drosophila melanogaster fruit fly. Mutations in the Ubx gene lead to transformation of appendages in the T2 and T3 segments, resulting in a second set of wings observed in the "bithorax" phenotype, illustrated on the cover. For further details, see Lewis, E.B. (1998), The bithorax complex: the first fifty years, Int. J. Dev. Biol. 42: 403-415, and Krumlauf, R. (2018), Hox genes, cluster and collinearity, Int. J. Dev. Biol. 62: 659-663. As early as 1978, it appeared that Hox genes contribute to controling the development of all bilaterian animals and are involved in a vast repertoire of biological activities. The seminal discoveries of homeotic genes paved the way for a wealth of research and engendered a community of scientists who perpetuate the excitement of revealing the world of Hox genes and HOX proteins.


Four decades of Hox gene investigation and many more to go
Françoise Gofflot, Lucie Jeannotte and René Rezsohazy
Int. J. Dev. Biol. (2018) 62: 653-657

Introductory papers

Hox genes, clusters and collinearity
Robb Krumlauf
Int. J. Dev. Biol. (2018) 62: 659-663
A scientific journey in the garden of the Hox genes: an interview with Jacqueline Deschamps
Françoise Gofflot, Lucie Jeannotte and René Rezsohazy
Int. J. Dev. Biol. (2018) 62: 665-671

Origin and regulation

Hox cluster genes and collinearities throughout the tree of animal life
Stephen J. Gaunt
Int. J. Dev. Biol. (2018) 62: 673-683
The remote transcriptional control of Hox genes
Claudia Gentile and Marie Kmita
Int. J. Dev. Biol. (2018) 62: 685-692
Regulatory landscape of the Hox transcriptome
Ana Casaca, Gabriel M. Hauswirth, Heidi Bildsoe, Moisés Mallo and Edwina Mcglinn
Int. J. Dev. Biol. (2018) 62: 693-704
Contributions of 5’HoxA/D regulation to actinodin evolution and the fin-to-limb transition
Robert L. Lalonde and Marie-Andrée Akimenko
Int. J. Dev. Biol. (2018) 62: 705-716
Mouse embryo Hox gene enhancers assayed in cell culture: Hoxb4, b8 and a7 are activated by Cdx1 protein
Stephen J. Gaunt
Int. J. Dev. Biol. (2018) 62: 717-722

HOX protein characteristics and action

Hox transcription factors: an overview of multi-step regulators of gene expression
Julie Carnesecchi, Pedro B. Pinto and Ingrid Lohmann
Int. J. Dev. Biol. (2018) 62: 723-732
Post-translational modifications of HOX proteins, an underestimated issue
Amandine Draime, Laure Bridoux, Yacine Graba and René Rezsohazy
Int. J. Dev. Biol. (2018) 62: 733-744
Evolution of the activation domain in a Hox transcription factor
Ying Liu, Annie Huang, Rebecca M. Booth, Gabriela Geraldo Mendes, Zabeena Merchant, Kathleen S. Matthews and Sarah E. Bondos
Int. J. Dev. Biol. (2018) 62: 745-753
Fattening the perspective of Hox protein specificity through SLiMming
Lucrezia Rinaldi, Andrew J. Saurin and Yacine Graba
Int. J. Dev. Biol. (2018) 62: 755-766

Biological and pathological functions of HOX proteins and co-factors

Developing roles for Hox proteins in hindbrain gene regulatory networks
Priyanjali Ghosh and Charles G. Sagerström
Int. J. Dev. Biol. (2018) 62: 767-774
Hox genes in the pharyngeal region: how Hoxa3 controls early embryonic development of the pharyngeal organs
Julie Gordon
Int. J. Dev. Biol. (2018) 62: 775-783
HOXA5 protein expression and genetic fate mapping show lineage restriction in the developing musculoskeletal system
Miriam A. Holzman, Jenna M. Bergmann, Maya Feldman, Kim Landry-Truchon, Lucie Jeannotte and Jennifer H. Mansfield
Int. J. Dev. Biol. (2018) 62: 785-796
Role of Hox genes in regulating digit patterning
Rocío Pérez-Gómez, Endika Haro, Marc Fernández-Guerrero, María F. Bastida and María A. Ros
Int. J. Dev. Biol. (2018) 62: 797-805
Emerging roles for HOX proteins in synaptogenesis
Françoise Gofflot and Benoit Lizen
Int. J. Dev. Biol. (2018) 62: 807-818
The genetics and the molecular functions of the PREP1 homeodomain transcription factor
Divya Purushothaman and Francesco Blasi
Int. J. Dev. Biol. (2018) 62: 819-825
Prep1 (pKnox1) transcription factor contributes to pubertal mammary gland branching morphogenesis
Lara Sicouri, Federica Pisati, Salvatore Pece, Francesco Blasi and Elena Longobardi
Int. J. Dev. Biol. (2018) 62: 827-836
Hox and Tale transcription factors in heart development and disease
Fabienne Lescroart and Stephane Zaffran
Int. J. Dev. Biol. (2018) 62: 837-846
HOX genes in normal, engineered and malignant hematopoiesis
Emma M. Collins and Alexander Thompson
Int. J. Dev. Biol. (2018) 62: 847-856
Lung cancer susceptibility genetic variants modulate HOXB2 expression in the lung
Alisson Clemenceau, Olivier Boucherat, Kim Landry-Truchon, Maxime Lamontagne, Sabrina Biardel, Philippe Joubert, Stéphane Gobeil, Blandine Secco, Mathieu Laplante, Mathieu Morissette, Ma’en Obeidat, Wim Timens, Lucie Jeannotte and Yohan Bossé
Int. J. Dev. Biol. (2018) 62: 857-864
A systematic survey of HOX and TALE expression profiling in human cancers
Yunlong Jia, Françoise Bleicher and Samir Merabet
Int. J. Dev. Biol. (2018) 62: 865-876

The International Journal of Developmental Biology
ISSN 1696-3547 (online) and 0214-6282 (print)