Vol. 60 Nos. 10/11/12 (2016) pp.321-420

Atlas of Human Experimental Teratomas

Cover legend

The teratoma essay has become the “gold standard” pluripotency test for stem cell lines. It involves the xenografting of human pluripotent stem cells (hPSC) into immunosuppressed mice in order to determine if they can produce teratomas containing derivatives of all the three embryonic germ layers. Xenografted hPSC may also recapitulate certain aspects of early embryonic development and form embryoid bodies and extra-embryonic tissues, such as yolk sac. In these cover images, we show representative differentiation patterns seen in human experimental teratomas. In the upper row, from the left, yolk sac elements, an embryoid body and several neural rosettes are shown. Below, examples of endoderm and mesoderm differentiation can be seen, together with a recipient immunosuppressed mouse. For more information, see article by Ivan Damjanov and Peter Andrews, pp. 337-419, in this issue. Mouse photo kindly reproduced with generous permission from the "Animal Resources Centre", Western Australia (www.arc.wa.gov.au).


Pluripotent human stem cells: Standing on the shoulders of giants
Ivan Damjanov and Peter W Andrews
Int. J. Dev. Biol. (2016) 60: 321-325

Symposium Report

Honoring the work and life of Leroy C. Stevens. A symposium as part of the International Stem Cell Initiative Workshop
Christopher F. Graham, Davor Solter, John D. Gearhart, Joseph H. Nadeau and Barbara B. Knowles
Int. J. Dev. Biol. (2016) 60: 327-336

Atlas of Human Experimental Teratomas

Teratomas produced from human pluripotent stem cells xenografted into immunodeficient mice - a histopathology atlas
Ivan Damjanov and Peter W. Andrews
Int. J. Dev. Biol. (2016) 60: 337-419

The International Journal of Developmental Biology
ISSN 1696-3547 (online) and 0214-6282 (print)