Vol. 57 Nos. 2/3/4 (2013) pp.101-332

Male Germ Cells in Development & Tumors

Cover legend

Corrosion cast of mouse testis showing the arrival of convoluted seminiferous tubules to the rete testis (lacuna testis in the mouse) through the straight tubules. A constricted portion connecting both types of testicular tubules can be observed. Pluripotent stem cells of the testis (spermatogonia) are housed in specific niches at the level of the basal region of the convoluted seminiferous tubules. These niches, whose walls are lined with Sertoli cells and peritubular mioid cells (covered by a basal lamina and colagen fibers) create a microenvironment which participates in the regulation of the mitotic and metabolic activity of spermatogonia and are the seat of the onset of testicular germ cell tumors. For further details, see Silván et al. in this issue (pages 185-195).

Preface

Male germ cells and cancer: a connection among pluripotency, differentiation and stem cell biology
Massimo De Felici and Susanna Dolci
Int. J. Dev. Biol. (2013) 57: 101-103

Primodial germ cells, male germ cells and germ cell tumors

A lifetime of migration
Peter Donovan and Christopher Wylie
Int. J. Dev. Biol. (2013) 57: 105-113
From testis to teratomas: a brief history of male germ cells in mammals
Massimo De Felici and Susanna Dolci
Int. J. Dev. Biol. (2013) 57: 115-121
Perceiving signals, building networks, reprogramming germ cell fate
Florencia Barrios, Naoko Irie and M. Azim Surani
Int. J. Dev. Biol. (2013) 57: 123-132
Classification, epidemiology and therapies for testicular germ cell tumours
Nikhil Vasdev, Andrew Moon and Andrew C. Thorpe
Int. J. Dev. Biol. (2013) 57: 133-139
Expression of FGFR3 during human testis development and in germ cell-derived tumours of young adults
Katherine A. Ewen, Inge A. Olesen, Sofia B. Winge, Ana R. Nielsen, John E. Nielsen, Niels Graem, Anders Juul and Ewa Rajpert-De Meyts
Int. J. Dev. Biol. (2013) 57: 141-151
Patient with two secondary somatic-type malignancies in a late recurrence of a testicular non-seminoma: illustration of potential and flaw of the cancer stem cell therapy concept
J.Wolter Oosterhuis, Suzanne H.P. Peeters, Vincent T.H.B.M. Smit, Hans Stoop, Leendert H.J. Looijenga, Henk W. Elzevier, Suzanne Osanto
Int. J. Dev. Biol. (2013) 57: 153-157

The control of male germ cell cycle and the spermatogonia stem cell “niche”

Role of cyclins in controlling progression of mammalian spermatogenesis
Debra J. Wolgemuth, Marcia Manterola and Ana Vasileva
Int. J. Dev. Biol. (2013) 57: 159-168
Cycling to and from a stem cell niche: the temporal and spatial odyssey of mitotic male germ cells
Christopher J. Payne
Int. J. Dev. Biol. (2013) 57: 169-177
Transcriptional control of KIT gene expression during germ cell development
Pellegrino Rossi
Int. J. Dev. Biol. (2013) 57: 179-184
The spermatogonial stem cell niche in testicular germ cell tumors
Unai Silván, Alejandro Díez-Torre, Pablo Moreno, Jon Arluzea, Ricardo Andrade, Margarita Silió and Juan Aréchaga
Int. J. Dev. Biol. (2013) 57: 185-195

Testicular teratomas and teratocarcinomas

Testicular germ cell tumors and related research from a historical point of view
Ivan Damjanov and Nicolai Wewer-Albrechtsen
Int. J. Dev. Biol. (2013) 57: 197-200
Testicular teratomas: an intersection of pluripotency, differentiation and cancer biology
Ximena Bustamante-Marín, Jason A. Garness and Blanche Capel
Int. J. Dev. Biol. (2013) 57: 201-210
Nodal/Cripto signaling in fetal male germ cell development: implications for testicular germ cell tumors
Cassy M. Spiller, Josephine Bowles and Peter Koopman
Int. J. Dev. Biol. (2013) 57: 211-219

Environmental endocrine disruptors and germ cell tumors

Carcinoma in situ -from clinical observation to a paradigm shift for testicular carcinogenesis
Jorma Toppari
Int. J. Dev. Biol. (2013) 57: 221-223
Endocrine disruptors, gene deregulation and male germ cell tumors
Jesús Del Mazo, Miguel A. Brieño-Enríquez, Jesús García-López, Luis A. López-Fernández and Massimo De Felici
Int. J. Dev. Biol. (2013) 57: 225-239
Development of malignant germ cells - the genvironmental hypothesis
Leendert H.J. Looijenga, Ton Van Agthoven and Katharina Biermann
Int. J. Dev. Biol. (2013) 57: 241-253
Effect of endogenous and exogenous hormones on testicular cancer: the epidemiological evidence
Fabrizio Giannandrea, Donatella Paoli, Irene Figà-Talamanca, Francesco Lombardo, Andrea Lenzi and Loredana Gandini
Int. J. Dev. Biol. (2013) 57: 255-263

Male germ cell apoptosis and DNA damage

Causes and consequences of apoptosis in spermatozoa; contributions to infertility and impacts on development
R. John Aitken and Mark A. Baker
Int. J. Dev. Biol. (2013) 57: 265-272
Revisiting DNA damage repair, p53-mediated apoptosis and cisplatin sensitivity in germ cell tumors
Francesca Cavallo, Darren R. Feldman and Marco Barchi
Int. J. Dev. Biol. (2013) 57: 273-280
UV and genotoxic stress induce ATR relocalization in mouse spermatocytes
Sara Di Siena, Federica Campolo, Pellegrino Rossi, Emmanuele A. Jannini, Susanna Dolci and Manuela Pellegrini
Int. J. Dev. Biol. (2013) 57: 281-287

New insights into the molecular mechanisms of germ cell tumors: pluripotency genes, epigenetics and

Pathobiology of germ cell tumors - applying the gossip test!
Leendert H. J. Looijenga and J. Wolter Oosterhuis
Int. J. Dev. Biol. (2013) 57: 289-298
Role of epigenetics in the etiology of germ cell cancer
Yvonne G. Van Der Zwan, Hans Stoop, Fernando Rossello,Stefan J. White and Leendert H.J. Looijenga
Int. J. Dev. Biol. (2013) 57: 299-308
Epigenetic features of testicular germ cell tumours in relation to epigenetic characteristics of foetal germ cells
Dina G. Kristensen, Niels E. Skakkebæk, Ewa Rajpert-De Meyts and Kristian Almstrup
Int. J. Dev. Biol. (2013) 57: 309-317
Role of stem cell proteins and microRNAs in embryogenesis and germ cell cancer
Ronak Eini, Lambert C. J. Dorssers and Leendert H. J. Looijenga
Int. J. Dev. Biol. (2013) 57: 319-332

The International Journal of Developmental Biology
ISSN 1696-3547 (online) and 0214-6282 (print)