Vol. 54 Nos. 6/7 (2010) pp.947-1212

Developmental Hematopoiesis

Cover legend

The beautiful drawing at the center represents a cross section through the area vasculosa of a 5 somite (embryonic day 8.5) rabbit embryo depicting a vessel formed by endothelial cells (Ed) within which primitive blood cells (pBlz) circulate. Two endothelial cells are changing their phenotype to give rise to round, hematopoietic cells (m). The endothelium is surrounded by a thin layer of cells designated as mesenchymal (x). Taken from Alexander A. Maximov (1909) Arch. Mikr. Anat. Entwickslungs. 73: 444-561. Encircling the drawing are the models elaborated upon in the present issue. Starting from the top to right: erythroid colony from mouse embryonic aorta (M. Souyri); E11.5 mouse embryo stained to reveal the vascular network (M. Souyri); Xenopus embryo, Stage 32 tail bud stage (V. Belo); zebrafish embryo (F. Giudicelli), 48hpf; Drosophila larva (F. Peronnet). Human embryo, Carnegie stage 12, 25-27 days post ovulation (H. Etchevers); avian embryo, HH15, 50-53h of development (C. Pouget). Composition: Sophie Gournet.

Developmental Hematopoiesis - Preface
Charles Durand, Thierry Jaffredo and Alexander Medvinsky
Int. J. Dev. Biol. (2010) 54: 947-949

ES cells and endo-hematopoietic differentiation

Developmental hematopoiesis: historical background and perspectives. An interview with Nicole Le Douarin
Charles Durand and Thierry Jaffredo
Int. J. Dev. Biol. (2010) 54: 951-954
Novel roles for Notch, Wnt and Hedgehog in hematopoesis derived from human pluripotent stem cells
Chantal Cerdan and Mickie Bhatia
Int. J. Dev. Biol. (2010) 54: 955-964
Challenges and strategies for generating therapeutic patient-specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cells
Ann Peters, Paul W. Burridge, Marina V. Pryzhkova, Michal A. Levine,Tea-Soon Park, Christopher Roxbury, Xuan Yuan, Bruno Péault and Elias T. Zambidis
Int. J. Dev. Biol. (2010) 54: 965-990
Dissecting hematopoietic differentiation using the embryonic stem cell differentiation model
Tara L. Huber
Int. J. Dev. Biol. (2010) 54: 991-1002

Sites of hematopoiesis: where do HSC and progenitors come from?

Novel methods for determining hematopoietic stem and progenitor cell emergence in the murine yolk sac
Christopher T. Lux and Mervin C. Yoder
Int. J. Dev. Biol. (2010) 54: 1003-1009
Primitive erythropoiesis in the mammalian embryo
James Palis, Jeffrey Malik, Kathleen E. McGrath and Paul D. Kingsley
Int. J. Dev. Biol. (2010) 54: 1011-1018
The origin and fate of yolk sac hematopoiesis: application of chimera analyses to developmental studies
Hiroo Ueno and Irving L. Weissman
Int. J. Dev. Biol. (2010) 54: 1019-1031
Primitive and definitive erythropoiesis in the yolk sac: a bird’s eye view
Guojun Sheng
Int. J. Dev. Biol. (2010) 54: 1033-1043
Aortic remodelling during hemogenesis: is the chicken paradigm unique?
Thierry Jaffredo, Charlotte Richard, Claire Pouget, Marie-Aimée Teillet, Karine Bollérot, Rodolphe Gautier and Cécile Drevon
Int. J. Dev. Biol. (2010) 54: 1045-1054
Hematopoietic stem cell activity in the Aorta-Gonad-Mesonephros region enhances after mid-day 11 of mouse development
Erin Taylor, Samir Taoudi and Alexander Medvinsky
Int. J. Dev. Biol. (2010) 54: 1055-1060
Embryonic origin of human hematopoiesis
Manuela Tavian, Katia Biasch, Lidia Sinka, Judith Vallet and Bruno Péault
Int. J. Dev. Biol. (2010) 54: 1061-1065
Mpl receptor defect leads to earlier appearance of hematopoietic cells/hematopoietic stem cells in the Aorta-Gonad-Mesonephros region, with increased apoptosis
Maud Fleury, Laurence Petit-Cocault, Denis Clay and Michèle Souyri
Int. J. Dev. Biol. (2010) 54: 1067-1074
The quest for hematopoietic stem cells in the embryo. An interview with Françoise Dieterlen-Lièvre
Thierry Jaffredo and Charles Durand
Int. J. Dev. Biol. (2010) 54: 1075-1078
Allantois and placenta as developmental sources of hematopoietic stem cells
Françoise Dieterlen-Lièvre, Catherine Corbel and Josselyne Salaün
Int. J. Dev. Biol. (2010) 54: 1079-1087
Hematopoietic stem cell development in the placenta
Christos Gekas, Katrin E. Rhodes, Ben Van Handel, Akanksha Chhabra, Masaya Ueno and Hanna K.A. Mikkola
Int. J. Dev. Biol. (2010) 54: 1089-1098
The placenta as a haematopoietic organ
Katrin Ottersbach and Elaine Dzierzak
Int. J. Dev. Biol. (2010) 54: 1099-1106

Genetic control of hematopoietic development in flies and vertebrates

Transcription factor interplay during Drosophila haematopoiesis
Lucas Waltzer, Vanessa Gobert, Dani Osman and Marc Haenlin
Int. J. Dev. Biol. (2010) 54: 1107-1115
Ontogeny of the Drosophila larval hematopoietic organ, hemocyte homeostasis and the dedicated cellular immune response to parasitism
Joanna Krzemien, Michele Crozatier and Alain Vincent
Int. J. Dev. Biol. (2010) 54: 1117-1125
Hematopoietic development in the zebrafish
Elizabeth J. Paik and Leonard I. Zon
Int. J. Dev. Biol. (2010) 54: 1127-1137
Genetic control of hematopoietic development in Xenopus and zebrafish
Aldo Ciau-Uitz, Feng Liu and Roger Patient
Int. J. Dev. Biol. (2010) 54: 1139-1149
Hematopoietic stem cell emergence in the conceptus and the role of Runx1
Gemma Swiers, Marella de Bruijn and Nancy A. Speck
Int. J. Dev. Biol. (2010) 54: 1151-1163
Definitive human and mouse hematopoiesis originates from the embryonic endothelium: a new class of HSCs based on VE-cadherin expression
Estelle Oberlin, Bouchra El Hafny, Laurence Petit-Cocault and Michèle Souyri
Int. J. Dev. Biol. (2010) 54: 1165-1173
The Notch pathway in the developing hematopoietic system
Anna Bigas, Àlex Robert-Moreno and Lluís Espinosa
Int. J. Dev. Biol. (2010) 54: 1175-1188
The roles of BMP and IL-3 signaling pathways in the control of hematopoietic stem cells in the mouse embryo
Catherine Robin and Charles Durand
Int. J. Dev. Biol. (2010) 54: 1189-1200

Stem cells and gene networking

Gene regulatory networks governing haematopoietic stem cell development and identity
John E. Pimanda and Berthold Göttgens
Int. J. Dev. Biol. (2010) 54: 1201-1211

The International Journal of Developmental Biology
ISSN 1696-3547 (online) and 0214-6282 (print)