Vol. 52 No. 1 (2008) pp.1-92

Cover legend

Anterior and posterior regions of the embryo are defined at early stages in development. In vertebrates, this is achieved, in part, by the posteriorising influence of secreted growth factors that are members of the fibroblast growth factor (FGF) and Wnt families of proteins. The photograph illustrates a gastrulation stage chick embryo showing anteriorly-restricted expression of Shisa2 mRNA. Shisa proteins prevent the maturation and transport to the cell surface of receptors for both FGFs and Wnts. It is proposed that this mechanism serves to maintain anterior identity by rendering cells in that region unresponsive to the influence of these posteriorising signals. For further details, see the article by Hedge and Mason, pp. 81-85, in this issue.

In memoriam of Anne McLaren
Marilyn Renfree and Roger Short
Int. J. Dev. Biol. (2008) 52: 1-2


Peter Holland, homeobox genes and the developmental basis of animal diversity
Sebastian M. Shimeld
Int. J. Dev. Biol. (2008) 52: 3-7


PBX proteins: much more than Hox cofactors
Audrey Laurent, Réjane Bihan, Francis Omilli, Stéphane Deschamps and Isabelle Pellerin
Int. J. Dev. Biol. (2008) 52: 9-20

Original Articles

Drosophila retinal pigment cell death is regulated in a position-dependent manner by a cell memory gene
Nicolas Dos-Santos, Thomas Rubin, Fabienne Chalvet, Pierre Gandille, Frederic Cremazy, Jacqueline Leroy, E. Boissonneau and Laurent Théodore
Int. J. Dev. Biol. (2008) 52: 21-31
Expression dynamics of the LIM-homeobox genes, Lhx1 and Lhx9, in the diencephalon during chick development
Xiangnan Sun, Hirotomo Saitsu, Kohei Shiota and Makoto Ishibashi
Int. J. Dev. Biol. (2008) 52: 33-41
Spa-1 regulates the maintenance and differentiation of human embryonic stem cells
Young-Jin Lee, Hee-Young Nah, Seok-Ho Hong, Ji-Won Lee, Ilkyung Jeon, Jhang Ho Pak, Joo-Ryung Huh, Sung-Hoon Kim, Hee-Dong Chae, Byung-Moon Kang, Chul Geun Kim and Chung-Hoon Kim
Int. J. Dev. Biol. (2008) 52: 43-53
TTF-1/NKX2.1 up-regulates the in vivo transcription of nestin
Roberta Pelizzoli, Carlo Tacchetti, Paola Luzzi, Antonella Strangio, Grazia Bellese, Emanuela Zappia and Stefania Guazzi
Int. J. Dev. Biol. (2008) 52: 55-62
Perichondrial-mediated TGF-beta regulation of cartilage growth in avian long bone development
Marsha L. Crochiere, James K. Kubilus and Thomas F. Linsenmayer
Int. J. Dev. Biol. (2008) 52: 63-70
Embryonic heat shock reveals latent hsp90 translation in zebrafish (Danio rerio)
Michelle H. Connolly and Brian K. Hall
Int. J. Dev. Biol. (2008) 52: 71-79

Developmental Expression Patterns

Expression of Shisa2, a modulator of both Wnt and Fgf signaling, in the chick embryo
Thomas A. Hedge and Ivor Mason
Int. J. Dev. Biol. (2008) 52: 81-85
Stromal-derived factor-1 (SDF-1) expression during early chick development
Rizwan Rehimi, Nargis Khalida, Faisal Yusuf, Fangping Dai, Gabriela Morosan-Puopolo and Beate Brand-Saberi
Int. J. Dev. Biol. (2008) 52: 87-92

The International Journal of Developmental Biology
ISSN 1696-3547 (online) and 0214-6282 (print)