The International Journal of Developmental Biology

Volume 48 > Issue 5-6 (Special Issue)

Cover Vol. 48 N. 5-6

Invasion in Cancer and Embryonic Development

Edited by: Marc Mareel and Juan Aréchaga

Cover Legend

"I do not understand my images and anyone is free to understand them as he wishes. I have only tried to depict my own dreams..." J.M. Folon. This neo-surrealist painting entitled "Invasion" by Jean-Michel Folon (1934, Brussels, Belgium), with its swirling components against a stable background can be considered as a representation of avid cells breaking through the basement membrane to invade the adjacent stroma. With kind permission from J.-M. Folon (2004)

OPEN ACCESS

Preface

Marc Mareel and Juan Aréchaga

Int. J. Dev. Biol. (2004) 48: 351-353

https://doi.org/10.1387/ijdb.041896mm

Oncogenes, tumor suppresor genes & genetic regulation

OPEN ACCESS

Molecular cell biology and cancer metastasis. An interview with Garth Nicolson

Marc Mareel

Int. J. Dev. Biol. (2004) 48: 355-363

https://doi.org/10.1387/ijdb.041803mm

Transcriptional regulation of cadherins during development and carcinogenesis

Héctor Peinado, Francisco Portillo and Amparo Cano

Int. J. Dev. Biol. (2004) 48: 365-375

https://doi.org/10.1387/ijdb.041794hp

APC dosage effects in tumorigenesis and stem cell differentiation

Claudia Gaspar and Riccardo Fodde

Int. J. Dev. Biol. (2004) 48: 377-386

https://doi.org/10.1387/ijdb.041807cg

Activities of invasive cells

OPEN ACCESS

Discovery and characterization of the cadherin family of cell adhesion molecules. An interview with Masatoshi Takeichi.

Douglas Sipp

Int. J. Dev. Biol. (2004) 48: 387-396

https://doi.org/10.1387/ijdb.041801ds

Cadherin-mediated cell-cell adhesion and tissue segregation in relation to malignancy

Ramsey A. Foty and Malcolm S. Steinberg

Int. J. Dev. Biol. (2004) 48: 397-409

https://doi.org/10.1387/ijdb.041810rf

Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies

Alicia R. Folgueras, Alberto M. Pendás, Luis M. Sánchez and Carlos López-Otín

Int. J. Dev. Biol. (2004) 48: 411-424

https://doi.org/10.1387/ijdb.041811af

Cytoskeletal mechanisms responsible for invasive migration of neoplastic cells

Jury M. Vasiliev

Int. J. Dev. Biol. (2004) 48: 425-439

https://doi.org/10.1387/ijdb.041806jv

Collective cell migration in morphogenesis and cancer

Peter Friedl, Yael Hegerfeldt and Miriam Tusch

Int. J. Dev. Biol. (2004) 48: 441-449

https://doi.org/10.1387/ijdb.041821pf

Invasive growth: a genetic program

Alessandra Gentile and Paolo M. Comoglio

Int. J. Dev. Biol. (2004) 48: 451-456

https://doi.org/10.1387/ijdb.041799ag

Invasion signalling pathways

From here to there; a life based on migration. An interview with Isaiah J. Fidler

Ian R. Hart

Int. J. Dev. Biol. (2004) 48: 457-462

https://doi.org/10.1387/ijdb.041790ih

N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling

Lara D.M. Derycke and Marc E. Bracke

Int. J. Dev. Biol. (2004) 48: 463-476

https://doi.org/10.1387/ijdb.041793ld

The Wnt connection to tumorigenesis

Jürgen Behrens and Barbara Lustig

Int. J. Dev. Biol. (2004) 48: 477-487

https://doi.org/10.1387/ijdb.041815jb

The chemokine network in cancer - much more than directing cell movement

Hagen Kulbe, Neil R. Levinson, Fran Balkwill and Julia L. Wilson

Int. J. Dev. Biol. (2004) 48: 489-496

https://doi.org/10.1387/ijdb.041814hk

Participation of the host

Brain tumour development and invasion. An interview with Ole Didrik Laerum

Dieter F. Hülser

Int. J. Dev. Biol. (2004) 48: 497-508

https://doi.org/10.1387/ijdb.041792dh

The stroma reaction myofibroblast: a key player in the control of tumor cell behavior

Alexis Desmoulière, Christelle Guyot and Giulio Gabbiani

Int. J. Dev. Biol. (2004) 48: 509-517

https://doi.org/10.1387/ijdb.041802ad

The countercurrent principle in invasion and metastasis of cancer cells. Recent insights on the roles of chemokines

Ghislain Opdenakker and Jo Van Damme

Int. J. Dev. Biol. (2004) 48: 519-527

https://doi.org/10.1387/ijdb.041796go

Normal embryonic invaders & their malignant counterparts

The migration and differentiation of a chemist entangled in developmental and cancer biology. An interview with Jean-Paul Thiery.

Fred T. Bosman

Int. J. Dev. Biol. (2004) 48: 529-535

https://doi.org/10.1387/ijdb.041795fb

Primordial germ cell migration

Kathleen Molyneaux and Christopher Wylie

Int. J. Dev. Biol. (2004) 48: 537-543

https://doi.org/10.1387/ijdb.041833km

OPEN ACCESS

Germinal tumor invasion and the role of the testicular stroma

Alejandro Díez-Torre, Unai Silván, Olivier De Wever, Erik Bruyneel, Marc Mareel and Juan Aréchaga

Int. J. Dev. Biol. (2004) 48: 545-557

https://doi.org/10.1387/ijdb.041897ad

Methodology

Tumor invasion and metastasis: getting more basic to come closer to the patient. An interview with Lance A. Liotta.

Vincent Castronovo

Int. J. Dev. Biol. (2004) 48: 559-562

https://doi.org/10.1387/ijdb.041834vc

The "chemoinvasion assay": a tool to study tumor and endothelial cell invasion of basement membranes

Adriana Albini, Roberto Benelli, Douglas M. Noonan and Claudio Brigati

Int. J. Dev. Biol. (2004) 48: 563-571

https://doi.org/10.1387/ijdb.041822aa

Novel technologies and recent advances in metastasis research

Ivana Crnic and Gerhard Christofori

Int. J. Dev. Biol. (2004) 48: 573-581

https://doi.org/10.1387/ijdb.041809ic

Therapeutic aspects

OPEN ACCESS

Parallels in invasion and angiogenesis provide pivotal points for therapeutic intervention

Suzanne A. Eccles

Int. J. Dev. Biol. (2004) 48: 583-598

https://doi.org/10.1387/ijdb.041820se

Pain control by ionizing radiation of bone metastasis

Luc A.M.-L. Vakaet and Tom Boterberg

Int. J. Dev. Biol. (2004) 48: 599-606

https://doi.org/10.1387/ijdb.041817lv