Vol. 48 Nos. 5/6 (2004) pp.349-606

Invasion in Cancer and Embryonic Development

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"I do not understand my images and anyone is free to understand them as he wishes. I have only tried to depict my own dreams..." J.M. Folon. This neo-surrealist painting entitled "Invasion" by Jean-Michel Folon (1934, Brussels, Belgium), with its swirling components against a stable background can be considered as a representation of avid cells breaking through the basement membrane to invade the adjacent stroma. With kind permission from J.-M. Folon (2004)

Preface
Marc Mareel and Juan Aréchaga
Int. J. Dev. Biol. (2004) 48: 351-353

Oncogenes, tumor suppresor genes & genetic regulation

Molecular cell biology and cancer metastasis. An interview with Garth Nicolson
Marc Mareel
Int. J. Dev. Biol. (2004) 48: 355-363 Transcriptional regulation of cadherins during development and carcinogenesis
Héctor Peinado, Francisco Portillo and Amparo Cano
Int. J. Dev. Biol. (2004) 48: 365-375 APC dosage effects in tumorigenesis and stem cell differentiation
Claudia Gaspar and Riccardo Fodde
Int. J. Dev. Biol. (2004) 48: 377-386

Activities of invasive cells

Discovery and characterization of the cadherin family of cell adhesion molecules. An interview with Masatoshi Takeichi.
Douglas Sipp
Int. J. Dev. Biol. (2004) 48: 387-396 Cadherin-mediated cell-cell adhesion and tissue segregation in relation to malignancy
Ramsey A. Foty and Malcolm S. Steinberg
Int. J. Dev. Biol. (2004) 48: 397-409 Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies
Alicia R. Folgueras, Alberto M. Pendás, Luis M. Sánchez and Carlos López-Otín
Int. J. Dev. Biol. (2004) 48: 411-424 Cytoskeletal mechanisms responsible for invasive migration of neoplastic cells
Jury M. Vasiliev
Int. J. Dev. Biol. (2004) 48: 425-439 Collective cell migration in morphogenesis and cancer
Peter Friedl, Yael Hegerfeldt and Miriam Tusch
Int. J. Dev. Biol. (2004) 48: 441-449 Invasive growth: a genetic program
Alessandra Gentile and Paolo M. Comoglio
Int. J. Dev. Biol. (2004) 48: 451-456

Invasion signalling pathways

From here to there; a life based on migration. An interview with Isaiah J. Fidler
Ian R. Hart
Int. J. Dev. Biol. (2004) 48: 457-462 N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling
Lara D.M. Derycke and Marc E. Bracke
Int. J. Dev. Biol. (2004) 48: 463-476 The Wnt connection to tumorigenesis
Jürgen Behrens and Barbara Lustig
Int. J. Dev. Biol. (2004) 48: 477-487 The chemokine network in cancer - much more than directing cell movement
Hagen Kulbe, Neil R. Levinson, Fran Balkwill and Julia L. Wilson
Int. J. Dev. Biol. (2004) 48: 489-496

Participation of the host

Brain tumour development and invasion. An interview with Ole Didrik Laerum
Dieter F. Hülser
Int. J. Dev. Biol. (2004) 48: 497-508 The stroma reaction myofibroblast: a key player in the control of tumor cell behavior
Alexis Desmoulière, Christelle Guyot and Giulio Gabbiani
Int. J. Dev. Biol. (2004) 48: 509-517 The countercurrent principle in invasion and metastasis of cancer cells. Recent insights on the roles of chemokines
Ghislain Opdenakker and Jo Van Damme
Int. J. Dev. Biol. (2004) 48: 519-527

Normal embryonic invaders & their malignant counterparts

The migration and differentiation of a chemist entangled in developmental and cancer biology. An interview with Jean-Paul Thiery.
Fred T. Bosman
Int. J. Dev. Biol. (2004) 48: 529-535 Primordial germ cell migration
Kathleen Molyneaux and Christopher Wylie
Int. J. Dev. Biol. (2004) 48: 537-543 Germinal tumor invasion and the role of the testicular stroma
Alejandro Díez-Torre, Unai Silván, Olivier De Wever, Erik Bruyneel, Marc Mareel and Juan Aréchaga
Int. J. Dev. Biol. (2004) 48: 545-557

Methodology

Tumor invasion and metastasis: getting more basic to come closer to the patient. An interview with Lance A. Liotta.
Vincent Castronovo
Int. J. Dev. Biol. (2004) 48: 559-562 The "chemoinvasion assay": a tool to study tumor and endothelial cell invasion of basement membranes
Adriana Albini, Roberto Benelli, Douglas M. Noonan and Claudio Brigati
Int. J. Dev. Biol. (2004) 48: 563-571 Novel technologies and recent advances in metastasis research
Ivana Crnic and Gerhard Christofori
Int. J. Dev. Biol. (2004) 48: 573-581

Therapeutic aspects

Parallels in invasion and angiogenesis provide pivotal points for therapeutic intervention
Suzanne A. Eccles
Int. J. Dev. Biol. (2004) 48: 583-598 Pain control by ionizing radiation of bone metastasis
Luc A.M.-L. Vakaet and Tom Boterberg
Int. J. Dev. Biol. (2004) 48: 599-606

The International Journal of Developmental Biology
ISSN 1696-3547 (online) and 0214-6282 (print)