Vol. 48 Nos. 2/3 (2004) pp.71-270
The cover picture highlights some of the problems in skin development which are currently en route to being resolved: a) how do regular repetitive structures, hairs or feathers, arise during embryogenesis? b) how is the dermis able to induce the formation of an epidermis with cutaneous appendages and their associated stem cells in any epithelium of ectoderm origin? c) how is the architecture of appendages controlled by the dermis? Foreground images: (Left) Feather primordia visualized by in situ staining for Shh (C.M. Chuong). In this example the dorsal feather pattern in a 7 day chick embryo is apparent. (Middle and Right) Examples of hair follicle induction by a wild type mouse embryonic dermis in Rosa 26 mouse amnion and corneal epithelium respectively; hair follicles were visualized by β-gal staining (D. Dhouailly and C. Jahoda). Background image: spiny barbules of a chick-type feather formed by a duck epidermis/chick dermis recombinant (D. Dhouailly).The choice between epidermal and neural fate: a matter of calcium.
The International Journal of Developmental Biology
ISSN 1696-3547 (online) and 0214-6282 (print)