Vol. 45 No. 1 (2001) pp.1-378

The Spemann-Mangold Organizer

Cover legend

Portrait photos of Hans Spemann (1869-1941) and Hilde Mangold, née Pröscholdt (1898-1924) on a background illustrating a page of H. Mangold´s laboratory notebook. One can clearly appreciate her careful histological analysis of two sections from the famous Um 132 experiment. The induction of a second embryonic axis after heterotransplantation of the upper blastoporal lip in a triton embryo is clearly apparent.

Preface
Eddy De Robertis and Juan Aréchaga
Int. J. Dev. Biol. (2001) 45: 0-0

Heritage of the 1924 article by Hans Spemann and Hilde Mangold

Introducing the Spemann-Mangold organizer: experiments and insights that generated a key concept in developmental biology.
K Sander and P E Faessler
Int. J. Dev. Biol. (2001) 45: 1-11 Induction of embryonic primordia by implantation of organizers from a different species. 1923.
H Spemann and H Mangold
Int. J. Dev. Biol. (2001) 45: 13-38 Developmental biology of amphibians after Hans Spemann in Germany.
H Grunz
Int. J. Dev. Biol. (2001) 45: 39-50 Spemann's heritage in Finnish developmental biology.
L Saxén
Int. J. Dev. Biol. (2001) 45: 51-55 Spemann's influence on Japanese developmental biology.
M Asashima and T S Okada
Int. J. Dev. Biol. (2001) 45: 57-65 Contribution of the Belgian school of embryology to the concept of neural induction by the organizer.
H Alexandre
Int. J. Dev. Biol. (2001) 45: 67-72 Contrasting influences of the organizer and induction concepts on the scientific activity of French embryologists.
J C Beetschen and A M Duprat
Int. J. Dev. Biol. (2001) 45: 73-81 Consequences of the Spemann-Mangold organizer concept for embryological research in Russia: personal impressions.
A T Mikhailov and N A Gorgolyuk
Int. J. Dev. Biol. (2001) 45: 83-96 The organizer concept and modern embryology: Anglo-American perspectives.
T J Horder
Int. J. Dev. Biol. (2001) 45: 97-132 Evolution of the organizer and the chordate body plan.
J Gerhart
Int. J. Dev. Biol. (2001) 45: 133-153 Continuity and change: paradigm shifts in neural induction.
S F Gilbert
Int. J. Dev. Biol. (2001) 45: 155-164 Formation and maintenance of the organizer among the vertebrates.
K Joubin and C D Stern
Int. J. Dev. Biol. (2001) 45: 165-175 Organizer and axes formation as a self-organizing process.
H Meinhardt
Int. J. Dev. Biol. (2001) 45: 177-188

Organizer research today

Molecular mechanisms of cell-cell signaling by the Spemann-Mangold organizer.
E M De Robertis, O Wessely, M Oelgeschläger, B Brizuela, E Pera, J Larraín, J Abreu and D Bachiller
Int. J. Dev. Biol. (2001) 45: 189-197 Formation of a functional morphogen gradient by a passive process in tissue from the early Xenopus embryo.
N McDowell, J B Gurdon and D J Grainger
Int. J. Dev. Biol. (2001) 45: 199-207 A study of Xlim1 function in the Spemann-Mangold organizer.
L Kodjabachian, A A Karavanov, H Hikasa, N A Hukriede, T Aoki, M Taira and I B Dawid
Int. J. Dev. Biol. (2001) 45: 209-218 Making mesoderm--upstream and downstream of Xbra.
J C Smith
Int. J. Dev. Biol. (2001) 45: 219-224 Regulation of convergent extension in Xenopus by Wnt5a and Frizzled-8 is independent of the canonical Wnt pathway.
J B Wallingford, K M Vogeli and R M Harland
Int. J. Dev. Biol. (2001) 45: 225-227 Generation of the germ layers along the animal-vegetal axis in Xenopus laevis.
H Yasuo and P Lemaire
Int. J. Dev. Biol. (2001) 45: 229-235 Dickkopf1 and the Spemann-Mangold head organizer.
C Niehrs, O Kazanskaya, W Wu and A Glinka
Int. J. Dev. Biol. (2001) 45: 237-240 Siamois cooperates with TGFbeta signals to induce the complete function of the Spemann-Mangold organizer.
M J Engleka and D S Kessler
Int. J. Dev. Biol. (2001) 45: 241-250 The Spemann-Mangold organizer: the control of fate specification and morphogenetic rearrangements during gastrulation in Xenopus.
T Bouwmeester
Int. J. Dev. Biol. (2001) 45: 251-258 Functional analysis of the Xenopus frizzled 7 protein domains using chimeric receptors.
R K Swain, A Medina and H Steinbeisser
Int. J. Dev. Biol. (2001) 45: 259-264 Fox (forkhead) genes are involved in the dorso-ventral patterning of the Xenopus mesoderm.
H El-Hodiri, N Bhatia-Dey, K Kenyon, K Ault, M Dirksen and M Jamrich
Int. J. Dev. Biol. (2001) 45: 265-271 In vitro induction systems for analyses of amphibian organogenesis and body patterning.
T Ariizumi and M Asashima
Int. J. Dev. Biol. (2001) 45: 273-279 The avian organizer.
T Boettger, H Knoetgen, L Wittler and M Kessel
Int. J. Dev. Biol. (2001) 45: 281-287 Nodal signaling and the zebrafish organizer.
A F Schier and W S Talbot
Int. J. Dev. Biol. (2001) 45: 289-297 The role of the homeodomain protein Bozozok in zebrafish axis formation.
L Solnica-Krezel and W Driever
Int. J. Dev. Biol. (2001) 45: 299-310 Role of the anterior visceral endoderm in restricting posterior signals in the mouse embryo.
A Perea-Gomez, M Rhinn and S L Ang
Int. J. Dev. Biol. (2001) 45: 311-320 Roles of Sox factors in neural determination: conserved signaling in evolution?
Y Sasai
Int. J. Dev. Biol. (2001) 45: 321-326 Getting your head around Hex and Hesx1: forebrain formation in mouse.
J P Martinez-Barbera and R S Beddington
Int. J. Dev. Biol. (2001) 45: 327-336 The role of Otx2 in organizing the anterior patterning in mouse.
A Simeone and D Acampora
Int. J. Dev. Biol. (2001) 45: 337-345 Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity.
S J Kinder, T E Tsang, S L Ang, R R Behringer and P P Tam
Int. J. Dev. Biol. (2001) 45: 347-355 Otx2 and HNF3beta genetically interact in anterior patterning.
O Jin, K Harpal, S L Ang and J Rossant
Int. J. Dev. Biol. (2001) 45: 357-365 The isthmic organizer and brain regionalization.
S Martínez
Int. J. Dev. Biol. (2001) 45: 367-371 Early neurogenesis in Amniote vertebrates.
N M Le Douarin
Int. J. Dev. Biol. (2001) 45: 373-378

The International Journal of Developmental Biology
ISSN 1696-3547 (online) and 0214-6282 (print)