Vol. 42 No. 7 (1998) pp.829-1074

Stem Cells and Transgenesis

Cover legend

Experimental modification of the germ line in animals has been critical to many recent advances in our understanding of biological phenomena, and the research contributions of Ralph Brinster that enabled and directed this field are depicted in the cover photographs. For details about these experiments and their influence on the field of germ line modification, see "Embryo culture, stem cells and experimental modification of the embryonic genome" by J. Aréchaga in this issue pp. 861-877.

Introductory papers

Egg culture: the foundation.
R E Hammer
Int. J. Dev. Biol. (1998) 42: 833-839 The coming of age of the transgenic era.
V E Papaioannou
Int. J. Dev. Biol. (1998) 42: 841-846 Transgenic mice--the early days.
R D Palmiter
Int. J. Dev. Biol. (1998) 42: 847-854 Germ cells and germ cell transplantation.
A McLaren
Int. J. Dev. Biol. (1998) 42: 855-860 Embryo culture, stem cells and experimental modification of the embryonic genome. An interview with Professor Ralph Brinster.
Juan Aréchaga
Int. J. Dev. Biol. (1998) 42: 861-878

Embryo culture, nutrition and manipulation

Reflections on the culture of the preimplantation embryo.
J D Biggers
Int. J. Dev. Biol. (1998) 42: 879-884 Culture of human preimplantation embryos to the blastocyst stage: a comparison of 3 media.
J Conaghan, K Hardy, H J Leese, R M Winston and A H Handyside
Int. J. Dev. Biol. (1998) 42: 885-893 Postimplantation mouse development: whole embryo culture and micro-manipulation.
P P Tam
Int. J. Dev. Biol. (1998) 42: 895-902

Stem cells

Mouse chimaeras revisited: recollections and reflections.
A K Tarkowski
Int. J. Dev. Biol. (1998) 42: 903-908 Neurulation in amniote vertebrates: a novel view deduced from the use of quail-chick chimeras.
N M Le Douarin, M A Teillet and M Catala
Int. J. Dev. Biol. (1998) 42: 909-916 Using EC and ES cell culture to study early development: recent observations on Indian hedgehog and Bmps.
L Grabel, S Becker, L Lock, P Maye and T Zanders
Int. J. Dev. Biol. (1998) 42: 917-925 Embryonic stem cells and transgenic mice in the study of hematopoiesis.
S H Orkin
Int. J. Dev. Biol. (1998) 42: 927-934 Liver disease and compensatory growth: unexpected lessons from genetically altered mice.
K M Braun and E P Sandgren
Int. J. Dev. Biol. (1998) 42: 935-942

Modification of the mammalian germline

Thirteen years of manipulating the mouse genome: a personal history.
A Bradley, B Zheng and P Liu
Int. J. Dev. Biol. (1998) 42: 943-950 Imprinting.
D Solter
Int. J. Dev. Biol. (1998) 42: 951-954 Genetics of mouse growth.
A Efstratiadis
Int. J. Dev. Biol. (1998) 42: 955-976 Immunoglobulin transgenes as targets for somatic hypermutation.
U Storb, A Peters, E Klotz, N Kim, H M Shen, J Hackett, B Rogerson, R O'Brien and T E Martin
Int. J. Dev. Biol. (1998) 42: 977-982 Analysis of transcriptional regulatory regions in vivo.
R J MacDonald and G H Swift
Int. J. Dev. Biol. (1998) 42: 983-994 Angiogenesis and apoptosis are cellular parameters of neoplastic progression in transgenic mouse models of tumorigenesis.
G Bergers, D Hanahan and L M Coussens
Int. J. Dev. Biol. (1998) 42: 995-1002 The use of transgenic animals in biotechnology.
K M Ebert
Int. J. Dev. Biol. (1998) 42: 1003-108 Insertional mutagenesis in transgenic mice generated by the pronuclear microinjection procedure.
R P Woychik and K Alagramam
Int. J. Dev. Biol. (1998) 42: 1009-1017 Transgenic studies of peripheral and central glia.
A Messing
Int. J. Dev. Biol. (1998) 42: 1019-1024 Comprehensive mammalian genetics: history and future prospects of gene trapping in the mouse.
B P Zambrowicz and G A Friedrich
Int. J. Dev. Biol. (1998) 42: 1025-1036 Developmental fates of the mouse germ cell line.
Y Matsui
Int. J. Dev. Biol. (1998) 42: 1037-1042 The germ cell--the mother of all stem cells.
P J Donovan
Int. J. Dev. Biol. (1998) 42: 1043-1050 A systematic molecular genetic approach to study mammalian germline development.
K Abe, M S Ko and G R MacGregor
Int. J. Dev. Biol. (1998) 42: 1051-1065 Male germ cell transplantation: present achievements and future prospects.
F X Jiang and R V Short
Int. J. Dev. Biol. (1998) 42: 1067-1073

The International Journal of Developmental Biology
ISSN 1696-3547 (online) and 0214-6282 (print)