Int J Dev Biol - Vol. 41 No. 5

Axis formation in Xenopus req uires cortical rotation and mesoderm induction. In untreated embryos (left embryo in cover picture) cortical rotation shifts a dorsalizing activity towards the future dorsal side. The expression domains of nr3 and sia, which are activated via a process ass ociated with the region of the prospective mesoderm in the marginal zone. In UV-treated em bryos (right embryo) cortical rotation is blocked and dorsal-specific genes are activated in cells at the vegetal pole after MBT. Due to the lack of overlap between their expressio n domain and the marginal zone, the expression of genes such as gsc cannot be maint ained outside the mesodermal region. Under these conditions, no organizer can form and no axis can be established. For details see "Cortical rotation is required for the correct s patial expression of nr3, sia and gsc in Xenopus embryos" by M edina et al. in this issue.

Relevance of proto-oncogenes as growth modulators in organogenesis of the mammalian embryonic kidney.
A Kumar, E I Wallner, F A Carone, D G Scarpelli and Y S Kanwar
Int. J. Dev. Biol. (1997) 41: 643-653

Homeobox genes from clusters A and B demonstrate characteristics of temporal colinearity and differential restrictions in spatial expression domains in the branching mouse lung.
R Mollard and M Dziadek
Int. J. Dev. Biol. (1997) 41: 655-666

Characterization and early embryonic expression of a neural specific transcription factor xSOX3 in Xenopus laevis.
R Penzel, R Oschwald, Y Chen, L Tacke and H Grunz
Int. J. Dev. Biol. (1997) 41: 667-677

Mouse molar morphogenesis revisited by three-dimensional reconstruction. III. Spatial distribution of mitoses and apoptoses up to bell-staged first lower molar teeth.
L Viriot, R Peterková, J L Vonesch, M Peterka, J V Ruch and H Lesot
Int. J. Dev. Biol. (1997) 41: 679-690

Isolation of cDNA clones for genes that are expressed in the tail region of the ascidian tailbud embryo.
H Takahashi, K Ishida, K W Makabe and N Satoh
Int. J. Dev. Biol. (1997) 41: 691-698

Developmental expression of H3.3A variant histone mRNA in mouse.
L A López-Fernández, D M López-Alañón, V Castañeda, D B Krimer and J del Mazo
Int. J. Dev. Biol. (1997) 41: 699-703

A 3' remote control region is a candidate to modulate Hoxb-8 expression boundaries.
I Valarché, W de Graaff and J Deschamps
Int. J. Dev. Biol. (1997) 41: 705-714

Targeted over-expression of FGF in chick embryos induces formation of ectopic neural cells.
L Rodríguez-Gallardo, V Climent, V Garciá-Martínez, G C Schoenwolf and I S Alvarez
Int. J. Dev. Biol. (1997) 41: 715-723

Distribution of BDNF and trkB mRNA in the otic region of 3.5 and 4.5 day chick embryos as revealed with a combination of in situ hybridization and tract tracing.
F Hallböök and B Fritzsch
Int. J. Dev. Biol. (1997) 41: 725-732

Shh, Fgf4 and Hoxd gene expression in the mouse limb mutant hypodactyly.
K E Robertson, C Tickle and S M Darling
Int. J. Dev. Biol. (1997) 41: 733-736

Contralateral efferent neurons can be detected in the hindbrain outside of rhombomere 4.
M Mallo
Int. J. Dev. Biol. (1997) 41: 737-739

Cortical rotation is required for the correct spatial expression of nr3, sia and gsc in Xenopus embryos.
A Medina, S R Wendler and H Steinbeisser
Int. J. Dev. Biol. (1997) 41: 741-745

Local origin of cells in FGF-4 - induced outgrowth of amputated chick wing bud stumps.
K Kostakopoulou, N Vargesson, J D Clarke, P M Brickell and C Tickle
Int. J. Dev. Biol. (1997) 41: 747-750

The International Journal of Developmental Biology
ISSN 1696-3547 (online) and 0214-6282 (print)

October 1997