TY  - JOUR
TI  - Differential spatiotemporal expression of E- and P-cadherin during mouse tooth development.
AU  - Palacios, J
AU  - Benito, N
AU  - Berraquero, R
AU  - Pizarro, A
AU  - Cano, A
AU  - Gamallo, C
T2  - The International Journal of Developmental Biology
AB  - Changes in E- and P-cadherin (E- and P-CD) expression during embryonic mouse first molar development were analyzed by immunohistochemistry. During the induction and morphogenesis stages (bud, cap and early bell stages), E-CD was expressed in the cells of the invaginating epithelial tooth bud and in the cells of the outer enamel epithelium, stellate reticulum and stratum intermedium, suggesting a role for this molecule in the maintenance of enamel organ architecture. On the other hand, P-CD was strongly expressed in the inner enamel epithelium suggesting its participation in the processes of mesenchymal induction. during the cytodifferentiation stage (late bell stage), E-CD was expressed in polarizing preameloblasts, but cadherin expression was restricted to the basal and apical poles of differentiated secretory ameloblasts, where the zonula adherens type of cell-cell junctions is located. The present study demonstrates for the first time the spatiotemporal expression of cadherins during tooth development and suggests differential and specific roles for E-CD and P-CD during the morphogenesis and cytodifferentiation processes of this organ.
PY  - 1995
VL  - 39
IS  - 4
SP  - 663
EP  - 666
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/8619966
Y2  - 2024/05/03/00:19:48
ER  -