TY  - JOUR
TI  - On the etiopathogenesis and therapy of Down syndrome.
AU  - Antila, E
AU  - Westermarck, T
T2  - The International Journal of Developmental Biology
AB  - The etiopathogenesis of Down syndrome is reviewed concentrating on the possible consequences of over-expression of cytoplasmic superoxide dismutase gene located in chromosome 21. Increased superoxide dismutase activity may generate free radical stress through overproduction of hydrogen peroxide. The significance of inadequate adaptive responses, i.e. increase of the selenoenzyme glutathione peroxidase activity in the central nervous system and in the thyroid gland is discussed. Suggestions are made for prevention of the progress of Down syndrome and intervention studies with antioxidant supplementation are proposed.
PY  - 1989
VL  - 33
IS  - 1
SP  - 183
EP  - 188
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/2534992
Y2  - 2024/05/06/09:47:57
ER  -