TY  - JOUR
TI  - Heterogeneity of quiescent and active neural stem cells in the postnatal brain
AU  - Dimitrakopoulos, Dimitrios
AU  - Kakogiannis, Dimitrios
AU  - Kazanis, Ilias
T2  - The International Journal of Developmental Biology
AB  - In the postnatal mammalian brain, neurogenic activity is retained in anatomically restricted areas, driven by pools of Neural Stem Cells (NSCs). These cells and their progeny have been studied intensively as potential targets for regenerative treatments, aiming at either their in situ manipulation or their use as sources of cells for transplantation-based strategies. Although their full identity, heterogeneity and differentiation potential remain elusive, due to the absence of specific cell-type markers, our knowledge of their properties is constantly expanding. Here, we focus on the NSC niche that is located at the Subependymal Zone (SEZ/ also known as Subventricular Zone) of the lateral ventricles of the brain. We review, summarize and explain the different faces of the NSC, as they have been described, using a wide range of experimental approaches, over a time-frame of three decades: the primitive, definitive, quiescent or activated NSC. We also review the growing evidence of the existence of latent NSCs outside of niches, in the brain parenchyma, that constitute promising new therapeutic targets, complemented by the novel technologies of in vivo cell reprogramming.      
PY  - 2022
DO  - 10.1387/ijdb.220010ik
VL  - 66
IS  - 1-2-3
SP  - 51
EP  - 58
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/220010ik
Y2  - 2024/04/29/15:55:21
ER  -