TY  - JOUR
TI  - Development of growth factor-incorporating liposomes for integration into scaffolds as a method to improve tissue regeneration
AU  - Natsaridis, E.
AU  - Mouzoura, P.
AU  - Gkartziou, F.
AU  - Marazioti, A.
AU  - Antimisiaris, S.G.
T2  - The International Journal of Developmental Biology
AB  - This review is an update with regard to the efforts to develop liposomal carriers for growth factor delivery. It is well known that growth factors have the potential to enhance/accelerate tissue regeneration; however, their poor stability, which results in rapid loss of their activity, together with their rapid clearance from defected tissues (when applied as free molecules) is a serious drawback for their use; their highly hydrophilic nature and low capability to permeate through biological barriers (cell membranes) are additional factors that limit their applicability. In recent years, the advantages of liposomal drug delivery systems have motivated efforts to deliver growth factors (GFs) in liposomal form. Herein, after briefly introducing the basic structural characteristics of liposome types and their advantages when used as drug carriers, as well as the basic problems encountered when GFs are applied for tissue regeneration, we focus on recent reports on the development and potential regenerative effects of liposomal GFs, towards defects of various tissues. The methodologies used for incorporation, attachment or immobilization of liposomal GFs in order to sustain their retention at the defected tissues are also highlighted.      
PY  - 2022
DO  - 10.1387/ijdb.210108sa
VL  - 66
IS  - 1-2-3
SP  - 137
EP  - 154
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/210108sa
Y2  - 2024/04/28/08:04:48
ER  -