TY  - JOUR
TI  - Diverse developmental strategies of X chromosome dosage compensation in eutherian mammals
AU  - Shevchenko, AlexanderI.
AU  - Dementyeva, ElenaV.
AU  - Zakharova, IrinaS.
AU  - Zakian, SurenM.
T2  - The International Journal of Developmental Biology
AB  - In eutherian mammals, dosage compensation arose to balance X-linked gene expression between sexes and relatively to autosomal gene expression in the evolution of sex chromosomes. Dosage compensation occurs in early mammalian development and comprises X chromosome upregulation and inactivation that are tightly coordinated epigenetic processes. Despite a uniform principle of dosage compensation, mechanisms of X chromosome inactivation and upregulation demonstrate a significant variability depending on sex, developmental stage, cell type, individual, and mammalian species. The review focuses on relationships between X chromosome inactivation and upregulation in mammalian early development.
PY  - 2019
DO  - 10.1387/ijdb.180376as
VL  - 63
IS  - 3-4-5
SP  - 223
EP  - 233
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/180376as
Y2  - 2024/04/29/08:56:04
ER  -