TY  - JOUR
TI  - The triumvirate of beta-cell regeneration: solutions and bottlenecks to curing diabetes
AU  - Singh, SumeetP.
AU  - Ninov, Nikolay
T2  - The International Journal of Developmental Biology
AB  - On 11 January 1922 insulin injection was used for the first time in the treatment of diabetes. Even today, daily insulin injections are the life-saving treatment for patients with Type 1 diabetes and advanced Type 2 diabetes. However, insulin injections often fail to achieve full glucose control, which in the long-term leads to multiple complications and mortality. Beta-cells, the natural producers and secretors of insulin, remain the gold-standard in regulating blood glucose levels. In this review, we focus on three strategies aiming at counteracting beta-cell loss in order to gain insulin independence: replacement, replication and protection. The three approaches, together termed as the triumvirate of beta-cell regeneration, may constitute the basis for a future cure for diabetes.
PY  - 2018
DO  - 10.1387/ijdb.180067nn
VL  - 62
IS  - 6-7-8
SP  - 453
EP  - 464
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/180067nn
Y2  - 2024/04/29/09:38:27
ER  -