TY  - JOUR
TI  - Comparative expression analysis of <I>cysteine-rich intestinal protein</I> family members <I>crip1, 2 and 3</I> during <I>Xenopus laevis</I> embryogenesis
AU  - Hempel, Annemarie
AU  - Kühl, SusanneJ.
T2  - The International Journal of Developmental Biology
AB  - Members of the cysteine-rich intestinal protein (Crip) family belong to the group 2 LIM proteins. Crip proteins are widely expressed in adult mammals but their expression profile and function during embryonic development are still mostly unknown. In this study, we have described for the first time the spatio-temporal expression pattern of the three family members crip1, crip2 and crip3 during Xenopus laevis embryogenesis by RT-PCR and whole mount in situ hybridization approaches. We observed that all three genes are expressed in the pronephros, branchial arches and the eye. Furthermore, crip1 transcripts could be visualized in the developing cranial ganglia and neural tube. In contrast, crip2 could be detected in the cardiovascular system, the brain and the neural tube while crip3 was expressed in the cranial ganglions and the heart. Based on these findings, we suggest that each crip family member may play an important role during embryonic development.
PY  - 2014
DO  - 10.1387/ijdb.140270sk
VL  - 58
IS  - 10-11-12
SP  - 841
EP  - 849
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/140270sk
Y2  - 2024/04/29/09:49:01
ER  -