TY  - JOUR
TI  - Gliolectin positively regulates Notch signalling during wing-vein specification in <I>Drosophila</I>
AU  - Prasad, Naveen
AU  - Shashidhara, LingadahalliS.
T2  - The International Journal of Developmental Biology
AB  - Notch signalling is essential for animal development. It integrates multiple pathways controlling cell fate and specification. Here we report the genetic characterization of Gliolectin, presumably a lectin, a cytoplasmic protein, significantly enriched in Golgi bodies. Its expression overlaps with regions where Notch is activated. Loss of gliolectin function results in ectopic veins, while gain of its function causes loss of wing veins. It positively regulates Enhancer of split m&beta;, a target of Notch signalling. These observations suggest that it is a positive regulator of Notch signalling during wing development in Drosophila.
PY  - 2015
DO  - 10.1387/ijdb.140190LS
VL  - 59
IS  - 4-5-6
SP  - 187
EP  - 194
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/140190LS
Y2  - 2024/05/05/22:10:22
ER  -