TY  - JOUR
TI  - Bmp, Fgf and Wnt signalling in programmed cell death and chondrogenesis during vertebrate limb development: the role of Dickkopf-1.
AU  - Grotewold, Lars
AU  - Ruther, Ulrich
T2  - The International Journal of Developmental Biology
AB  - Dickkopf-1 (Dkk-1) is a potent head inducer in Xenopus. This effect can be attributed to its capability to specifically inhibit Wnt/beta-catenin signalling. Recent data point to a crucial role for Dkk-1 in the control of programmed cell death during vertebrate limb development. In this paper, we present a comparative expression analysis of Dkk-1, Bmp-4 and Sox-9 as well as data on the regulation of Dkk-1 by Wnt. Finally, we summarize the current knowledge of its potential function in the developing limb and present a model how the interplay of the Bmp, Fgf and Wnt signalling pathways might differentially regulate programmed cell death versus chondrogenic differentiation in limb mesodermal cells.
PY  - 2002
VL  - 46
IS  - 7
SP  - 943
EP  - 947
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/12455632
Y2  - 2024/04/28/02:57:17
ER  -