TY  - JOUR
TI  - Involvement of adipokines, AMPK, PI3K and the PPAR signaling pathways in ovarian follicle development and cancer
AU  - Dupont, Joëlle
AU  - Reverchon, Maxime
AU  - Cloix, Lucie
AU  - Froment, Pascal
AU  - Ramé, Christelle
T2  - The International Journal of Developmental Biology
AB  - The physiological mechanisms that control energy balance are reciprocally linked to those that control reproduction, and together, these mechanisms optimize reproductive success under fluctuating metabolic conditions. Adipose tissue plays an important role in this regulation. Indeed, it releases a variety of factors, termed adipokines that regulate energy metabolism, but also reproductive functions. This article summarizes the function and regulation of some better-characterized adipokines (leptin, adiponectin, resistin, visfatin, chemerin and apelin) involved in ovarian follicle development. The follicle appears to use various “nutrient sensing” mechanisms that may form the link between nutrient status and folliculogenesis. This review examines evidence for the presence of pathways that may sense nutrient flux from within the follicle including the PI3K/Akt pathway, adenosine monophosphate-activated kinase (AMPK), and peroxisome proliferator-activated receptors (PPARs). It also reviews current information on the role of these adipokines and signalling pathways in ovarian cancers.
PY  - 2012
DO  - 10.1387/ijdb.120134jd
VL  - 56
IS  - 10-11-12
SP  - 959
EP  - 967
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/120134jd
Y2  - 2024/04/29/03:50:42
ER  -