TY  - JOUR
TI  - An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue
AU  - Hendrix, An
AU  - Lambein, Kathleen
AU  - Westbroek, Wendy
AU  - Seabra, MiguelC.
AU  - Cocquyt, Veronique
AU  - Pauwels, Patrick
AU  - Bracke, Marc
AU  - Gespach, Christian
AU  - Wever, OlivierDe
T2  - The International Journal of Developmental Biology
AB  - Regulated secretory pathways coordinated by small Rab GTPases are critically involved in intercellular communications. Here, we report the expression and localization of Rab27B in developing and differentiated epithelial human tissues by immunohistochemistry. Rab27B is poorly expressed in fetal tissues suggesting that several developmental mechanisms involved in epithelial differentiation and functions are mediated by other secretory Rab GTPases, such as Rab27A or Rab3 family members. In adult tissues, Rab27B is expressed in a wide variety of differentiated secretory epithelial cells, including those lining the salivary gland, gastrointestinal, mammary and prostate tracts. The complex pattern of Rab27B expression indicates that dysregulation of Rab27B-mediated secretion may have profound implications for disease pathology.
PY  - 2012
DO  - 10.1387/ijdb.120008ah
VL  - 56
IS  - 5
SP  - 363
EP  - 368
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/120008ah
Y2  - 2024/05/03/16:57:03
ER  -