TY  - JOUR
TI  - Expression of serotonergic system components during early <I>Xenopus</I> embryogenesis
AU  - Nikishin, DenisA.
AU  - Kremnyov, StanislavV.
AU  - Konduktorova, VictoriaV.
AU  - Shmukler, YuriB.
T2  - The International Journal of Developmental Biology
AB  - Despite abundant research studies on the physiological and biochemical nature of embryonic neurotransmitter function, little is known about the molecular genetic mechanisms involved.  The expression of the main components of the serotonergic system during early Xenopus embryogenesis was investigated using RT-PCR, real time PCR and in situ hybridization. Transcripts encoding the serotonin receptors HTR2C and HTR7, as well as the vesicular monoamine transporter VMAT2, the serotonin transporter (SERT) and the serotonin synthesis enzymes tryptophan hydroxylase (TPH2) and aromatic amino acid decarboxylase (AAAD) were found to be expressed during the cleavage division stages, whereas the degradation enzyme monoamine oxidase A (MAOA) was absent. The main components of the serotonergic system were found to be expressed during the earliest stages of embryonic development. The embryonic transmitter mechanism, its complexity, and its variability among various species are discussed. 
PY  - 2012
DO  - 10.1387/ijdb.113475dn
VL  - 56
IS  - 5
SP  - 385
EP  - 391
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/113475dn
Y2  - 2024/05/03/01:56:46
ER  -