TY  - JOUR
TI  - Wnt signaling in planarians: new answers to old questions
AU  - Almuedo-Castillo, Maria
AU  - Sureda-Gómez, Miquel
AU  - Adell, Teresa
T2  - The International Journal of Developmental Biology
AB  - Wnts are secreted glycoproteins involved in a broad range of essential cell functions, including proliferation, migration and cell-fate determination. Recent years have seen substantial research effort invested in elucidating the role of the Wnt signaling pathway in planarians, flatworms with incredible regenerative capacities. In this review, we summarize current knowledge on the role of canonical (β-catenin-dependent) and non-canonical (β-catenin-independent) Wnt signaling in planarians, not only during regeneration, but also during normal homeostasis. We also describe some of the preliminary data that has been obtained regarding the role of these pathways during embryogenesis. Models are proposed to integrate the different results which have been obtained to date and highlight those questions that still remain to be answered.
PY  - 2012
DO  - 10.1387/ijdb.113451ma
VL  - 56
IS  - 1-2-3
SP  - 53
EP  - 65
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/113451ma
Y2  - 2024/05/02/04:04:22
ER  -