TY  - JOUR
TI  - Cloning and developmental expression of zebrafish pdzrn3
AU  - Dente, Luciana
AU  - Gestri, Gaia
AU  - Tsang, Michael
AU  - Kudoh, Tetsuhiro
AU  - Wilson, StephenW.
AU  - Dawid, IgorB.
AU  - Andreazzoli, Massimiliano
T2  - The International Journal of Developmental Biology
AB  - Pdzrn3, a member of the PDZRN/SEMCAP/LNX protein family containing a RING finger and two PDZ domains, has been implicated in myoblast and osteoblast differentiation. However, its spatio-temporal expression pattern during embryonic development has not been defined. Here, we describe the cloning and expression pattern of pdzrn3 during zebrafish development. We found that in addition to being expressed in several mesodermal structures, this gene displays specific expression in the central nervous system including rhombomere 1, ventral retina, thalamus and motor neurons, indicating a novel function during neural development. In particular, the absence of expression of pdzrn3 in the ventral retina of noi mutant fish suggests a possible role for this gene in regulating fasciculation and/or navigation of retinal ganglion cell axons.
PY  - 2011
DO  - 10.1387/ijdb.113437ld
VL  - 55
IS  - 10-11-12
SP  - 989
EP  - 993
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/113437ld
Y2  - 2024/04/29/14:49:45
ER  -