TY  - JOUR
TI  - Opposing actions of histone deacetylase 1 and Notch signalling restrict expression of <I>erm</I> and <I>fgf20a</I> to hindbrain rhombomere centres during zebrafish neurogenesis
AU  - Lightman, ElewysG.
AU  - Harrison, MichaelR.M.
AU  - Cunliffe, VincentT.
T2  - The International Journal of Developmental Biology
AB  - The rate and pattern of neurogenesis in the developing vertebrate nervous system is controlled by a complex interplay of intercellular signalling pathways and transcriptional control mechanisms. In the zebrafish hindbrain, Fgf20a promotes transcription of the gene encoding the ETS-domain transcription factor Erm in the non-neurogenic centres of rhombomeres. Here, we demonstrate that the epigenetic regulator, Histone Deacetylase 1 (Hdac1) and the Notch signalling pathway have opposing functions in regulating expression of both erm and fgf20a in the zebrafish hindbrain. Our results show that Hdac1 is required for expression of erm and fgf20a in rhombomeres, and that the Hdac1-dependent expression of these two genes is attenuated in rhombomere boundary regions by Notch signalling activity, thereby restricting erm and fgf20a transcripts to narrow stripes of cells at rhombomere centres.
PY  - 2011
DO  - 10.1387/ijdb.113315el
VL  - 55
IS  - 6
SP  - 597
EP  - 602
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/113315el
Y2  - 2024/04/30/11:29:22
ER  -