TY  - JOUR
TI  - A SET/MYND chromatin re-modelling protein regulates <I>Dictyostelium</I> prespore patterning 
AU  - Nuñez-Corcuera, Beatriz
AU  - Birch, Joanna
AU  - Williams, JeffreyG.
T2  - The International Journal of Developmental Biology
AB  - SmdA is a Dictyostelium orthologue of the SET/MYND chromatin re-modelling proteins. In developing structures derived from a null mutant for smdA (a smdA- strain), prestalk patterning is normal, but using a prespore lacZ reporter fusion, there is ectopic accumulation of beta-galactosidase in the prestalk region. As wild type slugs migrate, there is continual forward movement and re-differentiation of prespore cells into prestalk cells. Thus, a potential explanation for the ectopic reporter localization in smdA null prestalk cells is an increased rate of re-differentiation and anterior movement of prespore cells. In support of this notion, analysis of an unstable lacZ reporter, driven by the prespore promoter, reveals a normal staining pattern in the smdA- strain. We suggest that one or more genes regulated by SmdA acts to repress prespore re-specification.
PY  - 2011
DO  - 10.1387/ijdb.113309bn
VL  - 55
IS  - 2
SP  - 205
EP  - 208
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/113309bn
Y2  - 2024/05/05/06:52:25
ER  -