TY  - JOUR
TI  - Dickkopf1 and the Spemann-Mangold head organizer.
AU  - Niehrs, C
AU  - Kazanskaya, O
AU  - Wu, W
AU  - Glinka, A
T2  - The International Journal of Developmental Biology
AB  - Work in amphibians indicates that inhibition of Wnt and BMP signals is essential for head development and that head induction by the Spemann-Mangold organizer may be mediated by secreted Wnt antagonists. Wnts are potent posteriorizing factors and antagonize the Spemann-Mangold organizer. Dickkopf1 (dkk1) encodes a secreted effector expressed in head organizing centers of Xenopus, mouse and zebrafish. It acts as a Wnt inhibitor and is able together with BMP inhibitors to induce the formation of ectopic embryonic heads in Xenopus. It anteriorizes both mesendoderm and neuroectoderm, promoting prechordal plate and forebrain fates. Injection of inhibitory antibodies leads to microcephaly and cyclopia. Dkk1 thus is an essential mediator of the vertebrate head organizer.
PY  - 2001
VL  - 45
IS  - 1
SP  - 237
EP  - 240
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/11291852
Y2  - 2024/04/29/23:49:11
ER  -