TY  - JOUR
TI  - The role of RXR-alpha in retinoic acid-induced cleft palate as assessed with the RXR-alpha knockout mouse.
AU  - Nugent, P
AU  - Sucov, H M
AU  - Pisano, M M
AU  - Greene, R M
T2  - The International Journal of Developmental Biology
AB  - Treatment of pregnant mice with retinoic acid (RA) in mid-gestation produces cleft palate and limb defects in the fetuses. RXR-alpha has been previously shown to mediate the teratogenic effects of RA in the limb. In this study, we show that RXR-alpha is also involved in retinoid-induced palatal clefting. Treatment of RXR-alpha knockout mice with a teratogenic dose of RA on gestation day 11 or 12 induces cleft palate at a lower frequency than that seen in wild-type animals.
PY  - 1999
VL  - 43
IS  - 6
SP  - 567
EP  - 570
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/10610030
Y2  - 2024/04/27/18:15:14
ER  -