TY  - JOUR
TI  - Wnts as kidney tubule inducing factors.
AU  - Vainio, S J
AU  - Itaranta, P V
AU  - Perasaari, J P
AU  - Uusitalo, M S
T2  - The International Journal of Developmental Biology
AB  - Since the discovery that inductive tissue interactions regulate nephrogenesis, one of the aims has been to identify the molecules that mediate this induction. The small size of embryonic tissue has limited the possibilities to identify the inducers biochemically, even though such efforts were directed to study, e.g. neural induction (for a comprehensive review, Saxén and Toivonen, Primary embryonic induction, Academic Press, London, 1962). The rapid progress in molecular biology made it possible to identify genes from minute amounts of tissue and provided techniques to generate recombinant proteins to assay their action in classic experimental systems. This led to the identification of some signals that are involved in primary and secondary inductive interactions during embryogenesis. Here, we will review evidence suggesting that secreted signaling molecules from the Wnt gene family mediate kidney tubule induction.
PY  - 1999
VL  - 43
IS  - 5
SP  - 419
EP  - 423
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/10535318
Y2  - 2024/05/03/00:01:21
ER  -