TY  - JOUR
TI  - Effect of the <i>transformer-2</i> gene of <i>Anastrepha</i> on the somatic sexual development of <i>Drosophila</i>
AU  - Sarno, Francesca
AU  - Ruiz, María-Fernanda
AU  - Sánchez, Lucas
T2  - The International Journal of Developmental Biology
AB  - The transformer-2 gene is involved in sex determination in tephritid flies (Tephritidae). It is required for the auto-regulation of the transformer gene (the memory device for sex determination in these insects) and for the female-specific splicing of doublesex pre-mRNA, the last gene in the sex determination gene cascade. The present manuscript addressed the question of the functional conservation of the tephritid Anastrepha Tra2 protein to direct sexual development in Drosophila (Drosophilidae). To express this protein in Drosophila, the GAL4-UAS system was used. The Anastrepha Tra2 protein supplies tra-2 function in Drosophila: this protein would form a complex with the endogenous Drosophila Tra protein to promote the female-specific splicing of the Drosophila doublesex pre-mRNA. The feminisation produced by the Anastrepha Tra2 protein was, however, partial.
PY  - 2011
DO  - 10.1387/ijdb.103279fs
VL  - 55
IS  - 10-11-12
SP  - 975
EP  - 979
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/103279fs
Y2  - 2024/04/29/03:04:13
ER  -