TY  - JOUR
TI  - Cancer stem cells and angiogenesis
AU  - Zhao, Yue
AU  - Bao, Qi
AU  - Renner, Andrea
AU  - Camaj, Peter
AU  - Eichhorn, Martin
AU  - Ischenko, Ivan
AU  - Angele, Martin
AU  - Kleespies, Axel
AU  - Jauch, Karl-Walter
AU  - Bruns, Christiane
T2  - The International Journal of Developmental Biology
AB  - Cancer stem cells (CSCs) or tumor initiating cells were identified and characterized as a unique subpopulation with stem cell features in many types of cancer. Current CSC studies provide novel insights regarding tumor initiation, progression, angiogenesis, resistance to therapy and interplay with the tumor micro-environment. A cancer stem cell niche has been proposed based on these findings. The niche provides the soil for CSC self-renewal and maintenance, stimulating essential signaling pathways in CSCs and leading to secretion of factors that promote angiogenesis and long term growth of CSCs. We present evidence which has emerged over the past 5 years indicating interaction of CSCs with angiogenesis in the proposed “vascular niche”. Based on these findings, targeting the “cancer stem cell niche” by combining an individualized anti-CSC approach with treatment of their microenvironment may represent a novel therapeutic strategy against solid tumor systems.
PY  - 2011
DO  - 10.1387/ijdb.103225yz
VL  - 55
IS  - 4-5
SP  - 477
EP  - 482
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/103225yz
Y2  - 2024/05/03/06:28:53
ER  -