TY  - JOUR
TI  - Fetal myoblast clones contribute to both fast and slow fibres in developing rat muscle.
AU  - Hughes, S M
T2  - The International Journal of Developmental Biology
AB  - Retroviral cell lineage marking was used to investigate the role of cell lineage in fetal and neonatal rat muscle development. Clusters of infected cells, presumably myoblast clones, contribute cells to both slow primary and fast secondary fibres. Moreover, single clusters of marked cells contain both slow and fast primary fibres, suggesting that, at least during fetal life, single clones contribute nuclei to both fibres that are committed to remain slow and those that convert to a fast phenotype. The majority of fibres in individual fascicles of fetal muscle could be infected by a self-inactivating retroviral vector. Retroviral gene expression was markedly lower in non-muscle tissues, suggesting that fetal retroviral infection might target exogenous genes to mammalian muscle fibres during later life.
PY  - 1999
VL  - 43
IS  - 2
SP  - 149
EP  - 155
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/10235391
Y2  - 2024/04/27/14:57:54
ER  -