TY  - JOUR
TI  - Pgk1 and Hprt gene activity in the peri-implantation mouse embryo is influenced by the parental origin of the X-chromosome.
AU  - Sturm, K
AU  - Lafferty, M
AU  - Tam, P P
T2  - The International Journal of Developmental Biology
AB  - The activity of two X-linked genes, Pgk1 and Hprt, that are localized on X-chromosomes of different parental origins in the XX mouse embryo was analyzed by the quantification of allele-specific transcripts. For the Pgk1 gene, the maternal allele-specific transcripts were consistently more abundant than the paternal transcripts in the blastocyst and the late gastrula. For the Hprt gene, the Hprt(b) allele was preferentially expressed in the blastocysts when it is present on the maternal X-chromosome. However, this skewed expression of the maternal allele was not observed in the reciprocal situation when the Hprt(a) allele was on the maternal X-chromosome. Like the Pgk1 locus, significantly more maternal Hprt transcripts were found in the gastrula-stage embryos irrespective of their genotypes. One possible interpretation of these results is that, in the XX mouse embryos, the genetic loci on maternal X-chromosome may be transcriptionally more active than their paternal counterparts during peri-implantation development.
PY  - 1999
VL  - 43
IS  - 1
SP  - 69
EP  - 73
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/10213084
Y2  - 2024/05/07/06:56:48
ER  -